The season started on August 13, 2000 and ended on June 10, 2001.
| Pos | Team | P | W | D | L | F | A | GD | Pts |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Živila Triglav Kranj | 29 | 22 | 4 | 3 | 68 | 19 | 49 | 70 |
| 2 | Esotech Šmartno | 29 | 19 | 5 | 5 | 60 | 31 | 29 | 62 |
| 3 | Aluminij Kidričevo | 29 | 18 | 6 | 5 | 62 | 29 | 33 | 60 |
| 4 | Jadran Hrpelje-Kozina | 29 | 17 | 5 | 7 | 55 | 31 | 24 | 56 |
| 5 | Elan Novo mesto | 29 | 16 | 3 | 10 | 46 | 41 | 5 | 51 |
| 6 | Dravinja | 29 | 12 | 5 | 12 | 28 | 36 | -8 | 41 |
| 7 | Viator&Vektor Ljubljana | 29 | 11 | 7 | 11 | 50 | 40 | 10 | 40 |
| 8 | Zagorje | 29 | 10 | 7 | 12 | 36 | 33 | 3 | 37 |
| 9 | Nafta Lendava | 29 | 10 | 7 | 12 | 32 | 31 | 1 | 37 |
| 10 | Železničar Maribor | 29 | 10 | 7 | 12 | 40 | 49 | -5 | 37 |
| 11 | Livar | 29 | 11 | 3 | 15 | 45 | 50 | -5 | 36 |
| 12 | Feroterm Pohorje | 29 | 8 | 7 | 14 | 28 | 54 | -26 | 31 |
| 13 | Beltinci | 29 | 6 | 7 | 16 | 37 | 60 | -23 | 25 |
| 14 | Šentjur | 15 | 6 | 3 | 6 | 23 | 27 | -4 | 21 |
| 15 | Brda1 | 29 | 5 | 2 | 22 | 39 | 74 | -35 | 17 |
| 16 | Renkovci | 29 | 3 | 4 | 22 | 35 | 79 | -44 | 13 |
| Promoted to Slovenian PrvaLiga | |
| Relegated to Slovenian Third League | |
| Withdrew from competition |
1 Brda merged with newly promoted Renče to avoid relegation.
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